Molecular Oncology Tests

The presence or absence of a specific gene mutation has been identified as a predictor of drug response. Testing for gene mutations prior to treatment ensures that the patient receives a drug that has the potential to work for them. 

The following molecular oncology panels using the Agena MassArray System are now available:

1. Colorectal Cancer Panel (KRAS, NRAS and BRAF)

2. Melanoma Panel (BRAF, KRAS)

3. Lung (NSCLC) Panel (EGFR, KRAS)

Cost: $483 including GST ($420 excl. GST)

This testing is generally performed on paraffin-embedded tissue. Testing may be available on other tissue types in specific circumstances. Please discuss your requirements directly with the laboratory.

Melanoma Panel

BRAF G466A, G466E, G466V, G469A, G469E, G469R, G469S, G469V, L597Q L597R, L597S, L597V, V600E, V600K, V600L, V600R, K601E

KIT W557G, W557R, V559A, V559D, V559G, L576P, K642E, D820Y

KRAS G12A, G12C, G12D, G12F,G12R, G12S, G12V, Q61L, Q61P, Q61R

NRAS G12C, G12R, G12S, G13C, G13R, G13S, Q61E, Q61H, Q61K, Q61L, Q61P, Q61R

Colon Panel

Genes

Coverage

# of mutations

BRAF

Codon 469 of exon 11; codons 549, 597 and 600 of exon 15

           20

KRAS

Codons 12, 13 of exon 2; codon 61 of exon 3; codon 146 of exon 4

            37

NRAS

Codons 12, 13 of exon 2 and codon 61 of exon 3

            20

Lung Panel

Genes

Coverage

# of mutations

BRAF

Codon 469 of exon 11; codons 549, 597 and 600 of exon 15

            20

EGFR

Substitutions, insertions and deletions across exons 18, 19, 20 and 21.

Includes key mutations such as L858R, L861Q and T790M

            125

KRAS

Codons 12, 13 of exon 2; codon 61 of exon 3; codon 146 of exon 4

              37

NRAS

Codons 12, 13 of exon 2 and codon 61 of exon 3

             20

RET Testing is also available

RET

C634R, C634W, C634Y, E632_L633del, M918T, A664D, A883F,
C634R, D631_L633>E, D631G, D898_E901del, E632_A640>VRP,
E768D, F612_C620del, F612_C620del

Requests can be made on our general referral form where you will also
find the specimen requirements.

Downloads
Contact

IGENZ Ltd
Level 2, Quay Park Health
68–70 Beach Road
Auckland

PO Box 106542
Auckland 1143
Phone 09 3073981
Fax 09 3073983
info@igenz.co.nz