Molecular Oncology Tests
The presence or absence of a specific gene mutation has been identified as a predictor of drug response. Testing for gene mutations prior to treatment ensures that the patient receives a drug that has the potential to work for them.
The following molecular oncology panels using the Agena MassArray System are now available:
1. Colorectal Cancer Panel (KRAS, NRAS and BRAF)
2. Melanoma Panel (BRAF, KRAS)
3. Lung (NSCLC) Panel (EGFR, KRAS)
Cost: $494.50 including GST ($430 excl. GST)
This testing is generally performed on paraffin-embedded tissue. Testing may be available on other tissue types in specific circumstances. Please discuss your requirements directly with the laboratory.
Melanoma Panel
BRAF G466A, G466E, G466V, G469A, G469E, G469R, G469S, G469V, L597Q L597R, L597S, L597V, V600E, V600K, V600L, V600R, K601E
KIT W557G, W557R, V559A, V559D, V559G, L576P, K642E, D820Y
KRAS G12A, G12C, G12D, G12F,G12R, G12S, G12V, Q61L, Q61P, Q61R
NRAS G12C, G12R, G12S, G13C, G13R, G13S, Q61E, Q61H, Q61K, Q61L, Q61P, Q61R
Colon Panel
|
Genes |
Coverage |
# of mutations |
|
BRAF |
Codon 469 of exon 11; codons 549, 597 and 600 of exon 15 |
20 |
|
KRAS |
Codons 12, 13 of exon 2; codon 61 of exon 3; codon 146 of exon 4 |
37 |
|
NRAS |
Codons 12, 13 of exon 2 and codon 61 of exon 3 |
20 |
Lung Panel
|
Genes |
Coverage |
# of mutations |
|
BRAF |
Codon 469 of exon 11; codons 549, 597 and 600 of exon 15 |
20 |
|
EGFR |
Substitutions, insertions and deletions across exons 18, 19, 20 and 21. Includes key mutations such as L858R, L861Q and T790M |
125 |
|
KRAS |
Codons 12, 13 of exon 2; codon 61 of exon 3; codon 146 of exon 4 |
37 |
|
NRAS |
Codons 12, 13 of exon 2 and codon 61 of exon 3 |
20 |
RET Testing is also available
RET
C634R, C634W, C634Y, E632_L633del, M918T, A664D, A883F,
C634R, D631_L633>E, D631G, D898_E901del, E632_A640>VRP,
E768D, F612_C620del, F612_C620del
Requests can be made on our general referral form where you will also
find the specimen requirements.
