Molecular Oncology Tests
The presence or absence of a specific gene mutation has been identified as a predictor of drug response. Testing for gene mutations prior to treatment ensures that the patient receives a drug that has the potential to work for them.
The following molecular oncology panels using the Agena MassArray System are now available:
Cost for panels 1-3: $600.00 including GST
1. Melanoma Panel (BRAF, KIT, KRAS and NRAS)
2. Colorectal Cancer Panel (KRAS, NRAS and BRAF)
3. Lung (NSCLC) Panel (BRAF, EGFR, KRAS)
Cost for panels 4-9 is available on request
4. GIST Panel*
5. Gynae Panel*
6. MLH1 methylation*
7. IDH1/2*
8. JAK2*
9. JAK2, MPL, MYD88 and CALR*
*Please email: info@igenz.co.nz to enquire about costs
This testing is generally performed on paraffin-embedded tissue. Testing may be available on other tissue types in specific circumstances. Please discuss your requirements directly with the laboratory.
Melanoma Panel
BRAF G466V, G469A, G469V, G469E, N581S, D594N, D594G, G593G, L597V, L597S, L597R, L597Q, V600M, V600K, V600R, V600E, V600G, V600D, V600V, K601E, V600_K601>E
KIT Y503_F504insAY, W557R, W557G, W557_K558del, V559A, V559D, V559G, V560D, L576P, K642E, V654A, T670I, D816H, D816Y, D816A, D816G, D816V, D820H, D820N, D820Y, D820A, D820G, D820V, D820E, N822H, N822Y, N822K, Y823D, A829P
KRAS K117N, G12D, G12V, G12A
NRAS G12C, G12R, G12S, G12D, G12A, G12V, G13R, G13C, G13S, G13D, G13A, G13V, Q61K, Q61E, Q61P, Q61R, Q61L, Q61H
Research genes:
GNA11 R183C, Q209L
GNAQ R183Q, Q209L, Q209P
HRAS Q61K, Q61L, Q61P
PTEN R130G, R130P, R130Q, R130L
RAC1 P29S
RPS27 Chr1:153963239C>T 5'UTR
TERT C228T, C250T
Colorectal:
BRAF G469E, D594G, V600E
KRAS A59S, A59T, A59E, A59G, Q61E, Q61K, Q61L, Q61P, Q61R, Q61H, G12C, G12R, G12S, K117R, K117N, G12A, G12D, G12V, G12G, G13C, G13R, G13S, G13A, G13D, G13V, G13G, A146P, A146T, A146G, A146V
NRAS A59T, A59G, Q61E, Q61K, Q61L, Q61P, Q61R, Q61H, K117E, G12C, G12R, G12S, K117R, K117N, G12A, G12D, G12V, G12G, G13C, G13R, G13S, G13A, G13D, G13V, A146P, A146S, A146T, A146G, A146V
Research genes:
EGFR S492R
PIK3CA E542K, E545K, H1047L, H1047R
Lung:
EGFR E709K, E709A, E709G, E709V, G719C, G719S, G719A, G719D, S768I, S768N, S768T, T790M, C797S, L858R, L861Q, L861R
Exon 19 deletions E746_E749delELRE, E746_A750>IP, E746_A750delELREA, E746_T751>I, E746_S752>I, E746_T751>IP, E746_S752delELREATS, E746_T751delELREAT, E746K, E746Q, E746_T751>V, E746_S752>V, E746_T751>A/E746_S752>A, E746_T751>VAorVP/E746_P753>VS, L747_A750>P, L747_S752delLREATS/L747_S752>Q, L747_E749delLRE, L747_T751>P/L747_P753>Q, L747_T751delLREAT, L747_P753>S/L747_T751>S, E749K, K745_E749delKELRE, L747_A750>P, A750E, A750A, L747_T751>Q, T751I, E746_S752>D, S752F, S752S
Exon 20 insertions M766V, D770_N771insSVD, D770N, D770H, D770Y, V769_D770insASV, D770>GY, V769_D770insASV, D770A, D770G, D770_N771insG, H773_V774insNPH, H773_V774insH, V774M
BRAF G469A, G469V, D594G, V600E
KRAS Q61E, Q61K, Q61L, Q61P, Q61R, Q61H, G12C, G12R, G12S, G12A, G12D, G12V, G13C, G13D
Research genes:
ERBB2 A775_G776insYVMA, G776>VC, G776>LC
PIK3CA
E542K, E545K, H1047L, H1047R
RET Testing is also available
RET
C634R, C634W, C634Y, E632_L633del, M918T, A664D, A883F,
C634R, D631_L633>E, D631G, D898_E901del, E632_A640>VRP,
E768D, F612_C620del, F612_C620del
Requests can be made on our general referral form where you will also
find the specimen requirements